Technical Challenges for Neglected Tropical Diseases Vaccines

The main challenges of NTD vaccine development are not confined to the discovery of antigens, adjuvants or delivery methods, but also to the product and clinical development of these vaccines. Product development is the prior most technological foundation which underlies the manufacture of new vaccines and also for it to successfully reach the targeted people for whom the vaccine is really made. The process of Clinical development is the testing in humans from phase 1 to phase 4 of the safety, immunogenicity and efficacy of that particular vaccine which is the first most and ultimate requirement in the development of the particular drug discovery.

  • Antigen discovery
  • Process development
  • Preclinical development
  • Clinical trials in resource-poor settings
  • The immune response to NTD infection

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